SCHEMBL1169874

SCHEMBL1169874

C=CC(OS(C)(=O)=O)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.39
MAPT P10636 5/20 0.39
HPGD P15428 4/20 0.39
CYP3A4 P08684 4/20 0.39
LMNA P02545 4/20 0.39
ALOX15 P16050 3/20 0.39
TDP1 Q9NUW8 3/20 0.39
USP2 O75604 2/20 0.39
TP53 P04637 2/20 0.39
HSD17B10 Q99714 2/20 0.39
ALOX12 P18054 1/20 0.39
ALDH1A1 P00352 5/20 0.36
KMT2A Q03164 4/20 0.36
MEN1 O00255 2/20 0.36
CYP24A1 Q07973 1/20 0.35
CYP2C19 P33261 1/20 0.33
SRC P12931 1/20 0.32
PMP22 Q01453 2/20 0.32
GMNN O75496 1/20 0.32
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL778796 0.85 MAPT (0.37) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL19717861 0.83 KMT2A (0.37) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL778797 0.81 SRC (0.40) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL17359706 0.81 CA1 (0.39) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL31069159 0.79 MAPT (0.35) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL3802806 0.78 CYP2C19 (0.36) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL2488648 0.78 CYP2C19 (0.36) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL18725670 0.77 MAPT (0.33) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL11814147 0.77 CYP1A2 (0.37) KDM4EMAPTHPGDCYP3A4LMNA
SCHEMBL4864044 0.77 C5AR1 (0.41) KDM4EHPGDCYP3A4LMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2215050-B1 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS NEUROTECH PHARMACEUTICALS CO LTD (KR) 2012-06-27 EP claimed
US-20110028757-A1 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2011-02-03 US claimed
EP-2215050-A2 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS Neurotech Pharmaceuticals Co., Ltd. (KR) 2010-08-11 EP claimed
WO-2009064084-A2 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS NEUROTECH CO., LTD. (KR) 2009-05-22 WO claimed
EP-2215050-B1 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS NEUROTECH PHARMACEUTICALS CO LTD (KR) 2012-06-27 EP disclosed
US-20110028757-A1 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS NEUROTECH PHARMACEUTICALS CO., LTD. (KR) 2011-02-03 US disclosed
EP-2215050-A2 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS Neurotech Pharmaceuticals Co., Ltd. (KR) 2010-08-11 EP disclosed
WO-2009064084-A2 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS NEUROTECH CO., LTD. (KR) 2009-05-22 WO disclosed
EP-0276920-B1 (2-CYANO-2-(PHENYL OR NAPHTHYL)-2-SUBSTITUTED-ETHYL) PYRAZINES, PYRIMIDINES AND PYRIDAZINES ROHM AND HAAS COMPANY (US) 1991-04-03 EP disclosed
EP-0276920-A1 (2-Cyano-2-(phenyl or naphthyl)-2-substituted-ethyl) pyrazines, pyrimidines and pyridazines ROHM AND HAAS COMPANY (US) 1988-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110028757-A1 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS PAH, HACL2, HAAO KDM4E 213/4885MAPT 3563/4885HPGD 679/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.