SCHEMBL11699862

SCHEMBL11699862

CCCC(c1cc(Cl)c(Cl)cc1OCc1ccc(Cl)c(Cl)c1)n1ccnc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 9/20 0.44
NPC1 O15118 3/20 0.40
RAB9A P51151 2/20 0.40
MAPT P10636 1/20 0.40
CYP3A4 P08684 1/20 0.40
ALDH1A1 P00352 2/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C19 P33261 1/20 0.38
CYP19A1 P11511 3/20 0.36
NR1I2 O75469 1/20 0.35
NR3C1 P04150 1/20 0.35
HTR1A P08908 1/20 0.35
ADORA3 P0DMS8 1/20 0.35
CNR1 P21554 1/20 0.35
TBXA2R P21731 1/20 0.35
SLC6A2 P23975 1/20 0.35
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
SLC6A4 P31645 1/20 0.35
ADRA1A P35348 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11702288 0.91 CYP19A1 (0.40) CYP17A1NPC1RAB9AMAPTCYP3A4
SCHEMBL11702953 0.91 CYP17A1 (0.42) CYP17A1NPC1RAB9AMAPTCYP3A4
SCHEMBL11701849 0.90 CYP17A1 (0.45) CYP17A1NPC1RAB9AMAPTCYP3A4
SCHEMBL11703364 0.89 SLC6A4 (0.48) CYP17A1CYP3A4CYP19A1NR1I2NR3C1
SCHEMBL11703636 0.85 CYP17A1 (0.40) CYP17A1NPC1RAB9AMAPTCYP3A4
SCHEMBL11703823 0.84 CYP17A1 (0.47) CYP17A1NPC1RAB9AMAPTCYP3A4
SCHEMBL11707276 0.83 CYP19A1 (0.45) CYP17A1MAPTCYP3A4ALDH1A1CYP2D6
SCHEMBL11703544 0.81 NPC1 (0.46) CYP17A1NPC1RAB9AMAPTCYP3A4
SCHEMBL11703004 0.79 CYP19A1 (0.48) CYP17A1CYP19A1NR1I2NR3C1HTR1A
SCHEMBL11706083 0.79 CYP19A1 (0.48) CYP17A1CYP19A1NR1I2NR3C1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4006243-A FUNGICIDE, BACTERICIDE, YEAST SCHERING AKTIENGESELLSCHAFT (DT) 1977-02-01 US claimed
US-4006243-A FUNGICIDE, BACTERICIDE, YEAST SCHERING AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed