Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8457574 | 0.91 | PSEN1 (0.45) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL11446496 | 0.85 | PSEN1 (0.47) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL7056637 | 0.85 | PSEN1 (0.47) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL11446495 | 0.85 | PSEN1 (0.47) | PSEN1MEN1KMT2APDE4APDE3A | |
| Methane SCHEMBL11453288 | 0.84 | PSEN1 (0.46) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL10536937 | 0.84 | PSEN1 (0.48) | PSEN1MEN1KMT2APDE4APDE3A | |
| Methane SCHEMBL11453290 | 0.84 | PSEN1 (0.46) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL10547297 | 0.84 | PSEN1 (0.48) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL10547295 | 0.84 | PSEN1 (0.48) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL11445897 | 0.84 | PSEN1 (0.43) | PSEN1MEN1KMT2APDE4APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4026907-A | INTERMEDIATES FOR ALPHA-TOCOPHEROL | HOFFMANN-LA ROCHE INC. (US) | 1977-05-31 | — | — | US | disclosed |
| US-4018799-A | INTERMEDIATES FOR TOCOPHEROL | HOFFMANN-LA ROCHE INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-4003919-A | INTERMEDIATES FOR ALPHA-TOCOPHEROL | HOFFMANN-LA ROCHE INC. (US) | 1977-01-18 | — | — | US | disclosed |
| US-3947473-A | (6-HYDROXY-CHROMAN-2-YL) CARBOXYLIC ACID DERIVATIVES | HOFFMAN-LA ROCHE INC. (US) | 1976-03-30 | — | — | US | disclosed |