Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.72 |
| ▸ | RAB9A | P51151 | 8/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11701941 | 0.91 | IRAK4 (0.76) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL11705956 | 0.86 | IRAK4 (0.69) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL2248250 | 0.84 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL31329345 | 0.82 | NPC1 (0.74) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL3595615 | 0.81 | IRAK4 (1.00) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL1973147 | 0.81 | IRAK4 (0.58) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL11700747 | 0.81 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL16766086 | 0.80 | CSNK1E (0.74) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL27756403 | 0.78 | IRAK4 (0.56) | NPC1RAB9AMEN1KMT2AIRAK4 | |
| SCHEMBL11707745 | 0.77 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2AIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4011236-A | N-(BENZIMIDAZOL-2-YL)ARYLCARBOXAMIDES AS ULTRAVIOLET (UV) LIGHT ABSORBERS | MERCK & CO., INC. (US) | 1977-03-08 | — | — | US | disclosed |