SCHEMBL11726239

SCHEMBL11726239

COC(=O)c1nc(Cl)cnc1OC

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.45
CCR4 P51679 8/20 0.40
KDM4E B2RXH2 3/20 0.37
ALDH1A1 P00352 2/20 0.37
PKM P14618 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GRM5 P41594 2/20 0.36
S1PR4 O95977 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31214143 0.86 NPSR1 (0.45) NPSR1CCR4KDM4EALDH1A1PKM
SCHEMBL20046668 0.84 NPSR1 (0.56) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL3581736 0.82 NPSR1 (0.48) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL29844710 0.81 GRM5 (0.52) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL361702 0.81 NPSR1 (0.47) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL261816 0.81 GRM5 (0.52) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL1475724 0.81 NPSR1 (0.47) NPSR1CCR4KDM4EALDH1A1SMN1; SMN2
SCHEMBL5274364 0.81 NPSR1 (0.47) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL23214139 0.79 NPSR1 (0.45) NPSR1KDM4EALDH1A1PKMSMN1; SMN2
SCHEMBL5274971 0.79 NPSR1 (0.45) NPSR1KDM4EALDH1A1PKMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260138991-A1 SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES MOMA THERAPEUTICS INC (US) 2026-05-21 US disclosed
EP-4705298-A2 SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES Moma Therapeutics, Inc. (US) 2026-03-11 EP disclosed
US-12559508-B2 Semi-saturated bicyclic derivatives and related uses MOMA THERAPEUTICS, INC. (US) 2026-02-24 US disclosed
US-20250230171-A1 SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES MOMA THERAPEUTICS, INC. 2025-07-17 US disclosed
WO-2024211836-A2 SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES MOMA THERAPEUTICS, INC. (US) 2024-10-10 WO disclosed
US-4041032-A ANTIEMATICS, GASTRIC MOTILITY STIMULANTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) 1977-08-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250230171-A1 SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES POLQ, POLB, POLK NPSR1 3684/4885CCR4 4622/4885KDM4E 2459/4885
US-20260138991-A1 SEMI-SATURATED BICYCLIC DERIVATIVES AND RELATED USES POLA1, SUB1, CTDSP1 NPSR1 2254/4885CCR4 1150/4885KDM4E 4515/4885
US-12559508-B2 Semi-saturated bicyclic derivatives and related uses POLA1, CTDSP1, SUB1 NPSR1 2680/4885CCR4 1282/4885KDM4E 4522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.