Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TDO2 | P48775 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11723855 | 0.94 | CYP3A4 (0.55) | CYP3A4MAPTTDO2IDO1TUBB4A | |
| Bromide SCHEMBL11729419 | 0.90 | CYP3A4 (0.53) | CYP3A4MAPTTDO2IDO1CDC42 | |
| Bromide SCHEMBL11724102 | 0.89 | CYP3A4 (0.46) | CYP3A4MAPTTDO2IDO1TUBB4A | |
| Bromide SCHEMBL11723876 | 0.89 | MAPT (0.48) | CYP3A4MAPTTDO2IDO1TUBB4A | |
| Bromide SCHEMBL11726933 | 0.88 | MAPT (0.45) | CYP3A4MAPTTUBB4ATUBBTUBA3C | |
| Bromide SCHEMBL11723835 | 0.87 | CYP3A4 (0.53) | CYP3A4MAPTTDO2IDO1MTNR1A | |
| Bromide SCHEMBL11727104 | 0.86 | MAPT (0.57) | CYP3A4MAPTTDO2IDO1TUBB4A | |
| Bromide SCHEMBL11728228 | 0.85 | CYP3A4 (0.56) | CYP3A4MAPTTDO2IDO1CDC42 | |
| Bromide SCHEMBL11730983 | 0.85 | CYP3A4 (0.60) | CYP3A4MAPTTDO2IDO1RAD52 | |
| Bromide SCHEMBL11727494 | 0.85 | CYP3A4 (0.60) | CYP3A4MAPTTDO2IDO1TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4042592-A | ANTISARCOMA GROWTH | KANEBO, LTD. (JA) | 1977-08-16 | — | — | US | disclosed |