Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Reserpine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 known ✓ | Q05940 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 13/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 13/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 1.00 |
| ▸ | TSHR | P16473 | 6/20 | 1.00 |
| ▸ | HBB | P68871 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | CASP1 | P29466 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | CASP7 | P55210 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Reserpine SCHEMBL20402680 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL15385127 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Isoreserpine SCHEMBL731599 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL4562878 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL12732449 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL8262666 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL14379427 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL5372164 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL22002247 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR | |
| Reserpine SCHEMBL29375859 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4ETDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1760737-B1 | USE OF AN ELECTROLYTE FOR DRIVING ELECTROLYTIC CAPACITOR AND ELECTROLYTIC CAPACITOR | RUBYCON CORP (JP) | 2018-10-31 | — | — | EP | claimed |
| EP-0403263-B1 | Method of manufacturing a luminescent screen assembly using a dry-powdered filming material | THOMSON CONSUMER ELECTRONICS (US) | 1994-03-02 | — | — | EP | claimed |
| US-20230256161-A9 | Methods and Compositions for Treating a Disease Condition in a Subject | Palo Alto Investors LP | 2023-08-17 | — | — | US | disclosed |
| WO-2023072128-A1 | COLORANT COMPOSITION AND COATED ARTICLE | GUANGDONG HUARUN PAINTS CO., LTD. (CN) | 2023-05-04 | — | — | WO | disclosed |
| WO-2022270460-A1 | (METH)ACRYLIC RESIN COMPOSITION, INORGANIC FINE PARTICLE-DISPERSED SLURRY COMPOSITION, AND INORGANIC FINE PARTICLE-DISPERSED MOLDED PRODUCT | 積水化学工業株式会社 | 2022-12-29 | — | — | WO | disclosed |
| US-11382513-B2 | Methods and compositions for treating a condition in a subject | PALO ALTO INVESTORS (US) | 2022-07-12 | — | — | US | disclosed |
| US-20210121625-A1 | Methods and Compositions for Treating a Disease Condition in a Subject | YUN ANTHONY JOONKYOO (US) | 2021-04-29 | — | — | US | disclosed |
| US-20200360271-A1 | Methods and Compositions for Treating a Renal Disease Condition in a Subject | Palo Alto Investors LP | 2020-11-19 | — | — | US | disclosed |
| US-10716749-B2 | Methods and compositions for treating a renal disease condition in a subject | PALO ALTO INVESTORS (US) | 2020-07-21 | — | — | US | disclosed |
| US-20180125419-A1 | Methods and Compositions for Treating a Condition in a Subject | PALO ALTO INVESTORS | 2018-05-10 | — | — | US | disclosed |
| EP-3310839-A1 | HYDROXYLATED AND/OR CARBOXYLATED POLYESTER RESIN WITH HIGH SOLIDS CONTENT AND HIGH COVERING POWER FOR COATING OF METAL FOIL | Arkema France (FR) | 2018-04-25 | — | — | EP | disclosed |
| US-20060116721-A1 | Methods and compositions for treating a disease condition in a subject | PALO ALTO INVESTORS | 2006-06-01 | — | — | US | disclosed |
| WO-2006044694-A2 | METHODS AND COMPOSITIONS FOR TREATING A DISEASE CONDITION IN A SUBJECT | PALO ALTO INVESTORS (US) | 2006-04-27 | — | — | WO | disclosed |
| EP-1620569-A2 | A FORWARD MUTATION ASSAY BASED ON 5-FLUOROURACIL RESISTANCE | Merck & Co., Inc. (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2005095394-A1 | A PROCESS FOR THE SEMISYNTHESIS OF DESERPIDINE | INDENA S.P.A. (IT) | 2005-10-13 | — | — | WO | disclosed |
| WO-2004096987-A2 | A FORWARD MUTATION ASSAY BASED ON 5-FLUOROURACIL RESISTANCE | MERCK & CO., INC. (US) | 2004-11-11 | — | — | WO | disclosed |
| EP-1468122-A1 | METHOD FOR THE SEPARATION OF ZINC AND A SECOND METAL WHICH DOES NOT FORM AN ANIONIC COMPLEX IN THE PRESENCE OF CHLORIDE IONS | SARP INDUSTRIES (FR) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062478-A1 | METHOD FOR THE SEPARATION OF ZINC AND A SECOND METAL WHICH DOES NOT FORM AN ANIONIC COMPLEX IN THE PRESENCE OF CHLORIDE IONS | SARP INDUSTRIES (FR) | 2003-07-31 | — | — | WO | disclosed |
| EP-1318762-A1 | ORTHODONTIC APPARATUS WITH RODS | Callabe, Elie (FR) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002022040-A1 | ORTHODONTIC APPARATUS WITH RODS | CALLABE ELIE (FR) | 2002-03-21 | — | — | WO | disclosed |