Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | SLC22A12 | Q96S37 | 11/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11462511 | 0.87 | AKR1B1 (0.56) | AKR1B1THRATHRBCA2SLC22A12 | |
| SCHEMBL21585558 | 0.81 | AKR1B1 (0.62) | AKR1B1THRATHRBCA2GAA | |
| SCHEMBL30496795 | 0.81 | TDP1 (0.66) | AKR1B1THRATHRBSLC22A12GAA | |
| SCHEMBL10343028 | 0.81 | AKR1B1 (0.58) | AKR1B1THRATHRBCA2GAA | |
| SCHEMBL31074301 | 0.80 | AKR1B1 (0.60) | AKR1B1THRATHRBSLC22A12GAA | |
| SCHEMBL11740239 | 0.80 | AKR1B1 (0.60) | AKR1B1THRATHRBSLC22A12GAA | |
| SCHEMBL27537426 | 0.80 | AKR1B1 (0.60) | AKR1B1THRATHRBGAANR1H4 | |
| SCHEMBL30557996 | 0.79 | AKR1B1 (0.84) | AKR1B1SLC22A12GAANR1H4PTGS1 | |
| SCHEMBL15352237 | 0.79 | CYP1A2 (0.48) | AKR1B1THRATHRBMEN1ALDH1A1 | |
| SCHEMBL10392245 | 0.79 | CYP1A2 (0.48) | AKR1B1THRATHRBCA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4045485-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC AND ANTIPRURITIC ACTIVITY | SYNTEX CORPORATION (US) | 1977-08-30 | — | — | US | disclosed |
| US-3960936-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, SKIN DISORDERS | SYNTEX CORPORATION (PM) | 1976-06-01 | — | — | US | disclosed |
| US-3947472-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (PM) | 1976-03-30 | — | — | US | disclosed |
| US-3935273-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (US) | 1976-01-27 | — | — | US | disclosed |