Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | TNF | P01375 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11744367 | 1.00 | GRM5 (0.54) | GRM5TNFMAPTSMN1; SMN2LMNA | |
| SCHEMBL11741806 | 0.99 | GRM5 (0.55) | GRM5TNFMAPTSMN1; SMN2LMNA | |
| SCHEMBL11741801 | 0.99 | GRM5 (0.55) | GRM5TNFMAPTSMN1; SMN2LMNA | |
| SCHEMBL11739760 | 0.95 | GRM5 (0.59) | GRM5TNFMAPTSMN1; SMN2LMNA | |
| SCHEMBL11739754 | 0.95 | GRM5 (0.59) | GRM5TNFMAPTSMN1; SMN2LMNA | |
| SCHEMBL11740982 | 0.86 | GRM5 (0.57) | GRM5MAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL11740985 | 0.86 | GRM5 (0.57) | GRM5MAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL11742691 | 0.84 | GRM5 (0.65) | GRM5SMN1; SMN2LMNARAB9AKDM4E | |
| SCHEMBL11741813 | 0.83 | GRM5 (0.67) | GRM5MAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL11741819 | 0.83 | GRM5 (0.67) | GRM5MAPTSMN1; SMN2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4046909-A | Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-06 | — | — | US | disclosed |
| US-3998958-A | Pyrrolidylidene, piperidylidene and hexahydroazepinylidene ureas as CNS depressants | MCNEIL LABORATORIES, INCORPORATED (US) | 1976-12-21 | — | — | US | disclosed |