Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.52 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351286 | 0.86 | TPMT (0.44) | TPMTHCAR1ALDH1A1MRGPRX4GLA | |
| SCHEMBL6646047 | 0.84 | TPMT (0.46) | TPMTHCAR1ALDH1A1MRGPRX4MEN1 | |
| SCHEMBL12326928 | 0.84 | TPMT (0.57) | TPMTHCAR1ALDH1A1MRGPRX4GLA | |
| SCHEMBL3348012 | 0.84 | TPMT (0.48) | TPMTHCAR1ALDH1A1MRGPRX4HCAR2 | |
| SCHEMBL3352072 | 0.83 | TPMT (0.44) | TPMTHCAR1MEN1KMT2A | |
| SCHEMBL1175842 | 0.83 | KDM4E (0.39) | ALDH1A1HDAC1SLC7A5TDP1MEN1 | |
| SCHEMBL3349426 | 0.83 | TPMT (0.47) | TPMTHCAR1ALDH1A1MRGPRX4HCAR2 | |
| SCHEMBL3351726 | 0.80 | TPMT (0.44) | TPMTHCAR1ALDH1A1MRGPRX4SLC7A5 | |
| SCHEMBL6647609 | 0.80 | TPMT (0.44) | TPMTHCAR1ALDH1A1MRGPRX4SLC7A5 | |
| SCHEMBL13501601 | 0.78 | TPMT (0.64) | TPMTHCAR1ALDH1A1MRGPRX4HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410151-B2 | Aminomethyl benzene derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2013-04-02 | — | — | US | disclosed |
| EP-2262782-B1 | NOVEL AMINOMETHYL BENZENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-07-04 | — | — | EP | disclosed |
| US-20110028449-A1 | NOVEL AMINOMETHYL BENZENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-02-03 | — | — | US | disclosed |
| EP-2262782-A1 | NOVEL AMINOMETHYL BENZENE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009109904-A1 | NOVEL AMINOMETHYL BENZENE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028449-A1 | NOVEL AMINOMETHYL BENZENE DERIVATIVES | CD47, BRD4, BRD3 | TPMT 58/4885HCAR1 976/4885ALDH1A1 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.