Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 12/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 12/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 12/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 12/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 12/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176209 | 1.00 | HDAC3 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1176548 | 0.87 | HDAC3 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1176549 | 0.87 | HDAC3 (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1175151 | 0.84 | HDAC1 (0.69) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1175156 | 0.84 | HDAC1 (0.69) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1176123 | 0.78 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1176128 | 0.78 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1176535 | 0.74 | KDM4E (0.46) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1175556 | 0.73 | HDAC3 (0.79) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL1175559 | 0.73 | HDAC3 (0.79) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115148-B2 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC S.R.L. (IT) | 2015-08-25 | — | — | US | disclosed |
| US-20140080823-A1 | SPIROCYCLIC DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | DAC S.R.L. (IT) | 2014-03-20 | — | — | US | disclosed |
| US-8592444-B2 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC S.R.L. (IT) | 2013-11-26 | — | — | US | disclosed |
| EP-2279187-B9 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC SRL (IT) | 2012-12-12 | — | — | EP | disclosed |
| EP-2279187-B1 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC SRL (IT) | 2012-04-25 | — | — | EP | disclosed |
| US-20110039840-A1 | SPIROCYCLIC DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | DAC S.R.L. (IT) | 2011-02-17 | — | — | US | disclosed |
| EP-2279187-A1 | SPIROCYCLIC DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | DAC S.r.l. (IT) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009127609-A1 | SPIROCYCLIC DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | DAC S.R.L. (IT) | 2009-10-22 | — | — | WO | disclosed |
| EP-2110377-A1 | Spirocyclic derivatives as histone deacetylase inhibitors | DAC S.r.l. (IT) | 2009-10-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039840-A1 | SPIROCYCLIC DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC7, HDAC8, HDAC9 | HDAC3 4/4885HDAC4 10/4885HDAC1 5/4885 |
| US-20140080823-A1 | SPIROCYCLIC DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS | HDAC7, HDAC8, HDAC9 | HDAC3 4/4885HDAC4 10/4885HDAC1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.