Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.40 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35915 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| Zinc Ion SCHEMBL1588842 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| Potassium Ion SCHEMBL338797 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| SCHEMBL5136382 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| SCHEMBL30774597 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| SCHEMBL4853327 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| SCHEMBL10651982 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| SCHEMBL1024108 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| SCHEMBL10652003 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 | |
| SCHEMBL982526 | 0.96 | KMT2A (0.44) | KMT2AKEAP1NFE2L2TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1944343-A1 | Self-dispersed inks for same orifice plate systems | Hewlett-Packard Development Company, L.P. (US) | 2008-07-16 | — | — | EP | claimed |
| EP-1616915-B1 | Self-dispersed black pigment ink formulation, ink-jet ink sets, and print system. | HEWLETT PACKARD DEVELOPMENT CO (US) | 2016-08-03 | — | — | EP | disclosed |
| EP-2142610-B1 | DYE-BASED INK FORMULATIONS | HEWLETT PACKARD DEVELOPMENT CO (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2222796-B1 | DYE-BASED GRAY INK FORMULATIONS, METHODS OF MAKING DYE-BASED GRAY INK FORMULATIONS, AND INK-JET INK SETS | HEWLETT PACKARD DEVELOPMENT CO (US) | 2013-06-12 | — | — | EP | disclosed |
| US-8328921-B2 | Dye-based gray ink formulations, methods of making dye-based gray ink formulations, and ink-jet ink sets | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2012-12-11 | — | — | US | disclosed |
| EP-1604833-B1 | Self-dispersed inks for same orifice plate systems | HEWLETT PACKARD DEVELOPMENT CO (US) | 2011-03-09 | — | — | EP | disclosed |
| US-7887627-B2 | Black, yellow, magenta, cyan dyes; improved quality, permanence, durability | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2011-02-15 | — | — | US | disclosed |
| US-20100288161-A1 | DYE-BASED GRAY INK FORMULATIONS, METHODS OF MAKING DYE-BASED GRAY INK FORMULATIONS, AND INK-JET INK SETS | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. | 2010-11-18 | — | — | US | disclosed |
| US-7828887-B2 | Dye-based ink formulations | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2010-11-09 | — | — | US | disclosed |
| EP-2222796-A1 | DYE-BASED GRAY INK FORMULATIONS, METHODS OF MAKING DYE-BASED GRAY INK FORMULATIONS, AND INK-JET INK SETS | Hewlett-Packard Development Company, L.P. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2007046924-A1 | INK JET PIGMENT INK FORMULATIONS AND SYSTEMS | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2007-04-26 | — | — | WO | disclosed |
| US-20070085887-A1 | Ink jet pigment ink formulations and systems | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. | 2007-04-19 | — | — | US | disclosed |
| US-20060207473-A1 | Ink formulations, print systems, and methods thereof | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. | 2006-09-21 | — | — | US | disclosed |
| WO-2006099609-A2 | INK FORMULATIONS, PRINT SYSTEMS, AND METHODS THEREOF | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2006-09-21 | — | — | WO | disclosed |
| WO-2006049738-A1 | INK FORMULATIONS, PRINT SYSTEMS, AND METHODS THEREOF | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060094796-A1 | Ink formulations, print systems, and methods thereof | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. | 2006-05-04 | — | — | US | disclosed |
| EP-1616915-A1 | Self-dispersed pigment ink formulations, ink-jet ink sets, print system, and methods of printing | Hewlett-Packard Development Company, L.P. (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20050275685-A1 | Self-dispersed inks for same orifice plate systems | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. | 2005-12-15 | — | — | US | disclosed |
| EP-1604833-A2 | Self-dispersed inks for same orifice plate systems | Hewlett-Packard Development Company, L.P. (US) | 2005-12-14 | — | — | EP | disclosed |
| US-4147545-A | FOR DIAZO-SENSITIZED PHOTOSENSITIVE COATINGS | POLYCHROME CORPORATION (US) | 1979-04-03 | — | — | US | disclosed |