Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.58 |
| ▸ | PI4KA | P42356 | 11/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.53 |
| ▸ | PIP5K1C | O60331 | 5/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799211 | 0.86 | PIK3CA (0.64) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL22470617 | 0.85 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL212263 | 0.85 | CYP2C9 (0.71) | PIK3CAPIK3CGPIK3CBPI4KBCYP3A4 | |
| SCHEMBL3709415 | 0.82 | PIK3CG (0.76) | PIK3CAPIK3CGPIK3CBPI4KBCYP3A4 | |
| SCHEMBL22470574 | 0.79 | CYP3A4 (0.54) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL22470682 | 0.78 | CYP3A4 (0.53) | PIK3CAPIK3CDPIK3CGPIK3CBPI4KB | |
| SCHEMBL1121708 | 0.77 | CYP3A4 (0.57) | PIK3CAPIK3CGPIK3CBPI4KBCYP3A4 | |
| SCHEMBL14364298 | 0.77 | KDM4E (0.54) | CA12CA1CA2CA9ERN1 | |
| SCHEMBL29627194 | 0.77 | ERN1 (0.52) | CA12CA1CA2CA9ERN1 | |
| SCHEMBL28753178 | 0.77 | ERN1 (0.52) | CA12CA1CA2CA9ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| CN-101877966-A | Farnesoid X receptor agonists | SMITHKLINE BEECHAM CORP | 2010-11-03 | — | — | CN | disclosed |
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | NR1H4, NR1H3, NR1H2 | PIK3CA 1754/4885PIK3CD 2940/4885PIK3CG 3066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.