Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 14/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179044 | 0.89 | TP53 (0.36) | TP53S1PR1POLBMAPTS1PR5 | |
| SCHEMBL1178826 | 0.81 | S1PR1 (0.41) | S1PR1S1PR3 | |
| SCHEMBL1179127 | 0.80 | S1PR1 (0.47) | KCNT1TP53S1PR1POLBMAPT | |
| SCHEMBL1179655 | 0.79 | S1PR1 (0.41) | TP53S1PR1S1PR5 | |
| SCHEMBL1179721 | 0.78 | S1PR1 (0.38) | S1PR1S1PR3S1PR5 | |
| SCHEMBL27828595 | 0.77 | MAPT (0.48) | TP53S1PR1POLBMAPTS1PR3 | |
| SCHEMBL3094985 | 0.76 | POLB (0.37) | TP53S1PR1POLBMAPT | |
| SCHEMBL3086386 | 0.74 | S1PR1 (0.48) | S1PR1S1PR3 | |
| SCHEMBL3086397 | 0.74 | S1PR1 (0.48) | S1PR1S1PR3 | |
| SCHEMBL3074510 | 0.74 | S1PR1 (0.51) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046170-A1 | NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-02-24 | — | — | US | claimed |
| US-20110046170-A1 | NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046170-A1 | NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES | TYMP, DPYD, ENTPD5 | KCNT1 3749/4885TP53 299/4885S1PR1 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.