Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417341 | 0.97 | — | — | |
| Iodide SCHEMBL11683597 | 0.79 | — | — | |
| SCHEMBL8244841 | 0.76 | — | — | |
| Iodide SCHEMBL10423707 | 0.75 | EPHX1 (0.40) | — | |
| SCHEMBL11674632 | 0.74 | KMT2A (0.35) | — | |
| Iodide SCHEMBL11646271 | 0.74 | EPHX1 (0.45) | — | |
| SCHEMBL27567582 | 0.72 | — | — | |
| SCHEMBL11060826 | 0.72 | — | — | |
| Iodide SCHEMBL11848669 | 0.72 | — | — | |
| SCHEMBL11844558 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610247-B1 | Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists | ABBVIE BAHAMAS LTD (BS) | 2016-05-25 | — | — | EP | disclosed |
| EP-2265589-B1 | ARYLSULFONYL PYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | ABBVIE BAHAMAS LTD (BS) | 2016-01-27 | — | — | EP | disclosed |
| US-9126942-B2 | Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists | ABBVIE BAHAMAS LIMITED (BS) | 2015-09-08 | — | — | US | disclosed |
| US-20150051239-A1 | ARYLSULFONYL PYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | ABBVIE BAHAMAS LIMITED (BS) | 2015-02-19 | — | — | US | disclosed |
| US-8901108-B2 | Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists | ABBVIE BAHAMAS LIMITED (BS) | 2014-12-02 | — | — | US | disclosed |
| US-20140303372-A1 | SULFONYLPYRAZOLE AND SULFONYLPYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | ABBVIE BHAMAS LTD. (BS) | 2014-10-09 | — | — | US | disclosed |
| US-8722887-B2 | Sulfonylpyrazole and sulfonylpyrazoline carboxamidine derivatives as 5-HT6 antagonists | Abbvie Bahamas, Ltd. (BS) | 2014-05-13 | — | — | US | disclosed |
| US-20140011775-A1 | ARYLSULFONYL PYRAZOLINE CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2014-01-09 | — | — | US | disclosed |
| US-8563723-B2 | Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists | ABBOTT HEALTHCARE PRODUCTS, B.V. (NL) | 2013-10-22 | — | — | US | disclosed |
| EP-2610247-A1 | Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists | Abbott Healthcare Products B.V. (NL) | 2013-07-03 | — | — | EP | disclosed |
| US-6858396-B2 | Positively charged non-natural amino acids, methods of making and using thereof in peptides | MEDICAL UNIVERSITY OF SOUTH CAROLINA (US) | 2005-02-22 | — | — | US | disclosed |
| US-6783946-B2 | CLOSELY REPLICATE THE NATURAL AMINO ACIDS LYSINE AND ARGININE. | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2004-08-31 | — | — | US | disclosed |
| US-6566330-B1 | As chemical intermediate | MEDICAL UNIVERSITY OF SOUTH CAROLINA FOUNDATION RESEARCH DEVELOPMENT | 2003-05-20 | — | — | US | disclosed |
| US-20020137730-A1 | Positively charged non-natural amino acids, methods of making and using thereof in peptides | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2002-09-26 | — | — | US | disclosed |
| US-20020068701-A1 | Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2002-06-06 | — | — | US | disclosed |
| US-6358922-B1 | ARGININE DERIVATIVES | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2002-03-19 | — | — | US | disclosed |
| US-6043218-A | Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides | MEDICAL UNIVERSITY OF SOUTH CAROLINA (US) | 2000-03-28 | — | — | US | disclosed |
| WO-1998017626-A2 | POSITIVELY CHARGED NON-NATURAL AMINO ACIDS, METHODS OF MAKING THEREOF, AND USE THEREOF IN PEPTIDES | MEDICAL UNIVERSITY OF SOUTH CAROLINA (US) | 1998-04-30 | — | — | WO | disclosed |
| US-4977189-A | Anxiolytic agents, cognition activators | AMERICAN CYANAMID COMPANY (US) | 1990-12-11 | — | — | US | disclosed |
| US-4056527-A | HERBICIDE | BAYER AKTIENGESELLSCHAFT (DT) | 1977-11-01 | — | — | US | disclosed |