Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180172 | 0.87 | KDM4E (0.53) | CYP11B1CYP11B2CYP1A2KDM4EHSD17B1 | |
| SCHEMBL2258923 | 0.86 | KDM4E (0.60) | CYP1A2CYP2D6CYP2C9CYP2C19KDM4E | |
| SCHEMBL1179257 | 0.85 | ESR2 (0.51) | CYP1A2CYP2D6CYP2C9CYP2C19HSD17B1 | |
| SCHEMBL13970550 | 0.82 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP1A2CYP2C9HSD17B1 | |
| SCHEMBL14063326 | 0.79 | KDM4E (0.79) | CYP11B1CYP11B2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL31337030 | 0.78 | CA12 (0.50) | HSD17B1SLC6A4SLC6A3 | |
| SCHEMBL22319386 | 0.78 | NR4A2 (0.55) | CYP1A2CYP2C19KDM4ESLC6A4SLC6A3 | |
| SCHEMBL15897010 | 0.78 | CYP11B1 (0.69) | CYP11B1CYP11B2CYP1A2KDM4EHSD17B1 | |
| SCHEMBL13828206 | 0.78 | SLC6A2 (0.56) | CYP11B1CYP11B2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL26882759 | 0.77 | KDM4E (0.57) | CYP11B1CYP11B2CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| EP-2173174-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009005998-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034507-A1 | FARNESOID X RECEPTOR AGONISTS | NR1H4, NR1H3, NR1H2 | CYP11B1 70/4885CYP11B2 113/4885CYP1A2 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.