Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL443703 | 1.00 | TDP1 (0.67) | TDP1TSHRCA5ACA5BTP53 | |
| Propylene Glycol SCHEMBL3441580 | 1.00 | TDP1 (0.67) | TDP1TSHRCA5ACA5BTP53 | |
| Propylene Glycol SCHEMBL575555 | 0.90 | TDP1 (0.62) | TDP1TSHRTP53ALDH1A1LMNA | |
| Propylene Glycol SCHEMBL575982 | 0.88 | TDP1 (0.59) | TDP1TSHRTP53ALDH1A1LMNA | |
| Propylene Glycol SCHEMBL28589912 | 0.85 | TDP1 (0.56) | TDP1TSHRTP53ALDH1A1GRIA1 | |
| Propylene Glycol SCHEMBL576545 | 0.83 | TDP1 (0.53) | TDP1TSHRTP53ALDH1A1 | |
| Propylene Glycol SCHEMBL577012 | 0.83 | TDP1 (0.53) | TDP1TSHRTP53ALDH1A1 | |
| Isobutanol SCHEMBL11251204 | 0.83 | TSHR (0.64) | TDP1TSHRCA5ACA5BTP53 | |
| Trolamine SCHEMBL23494826 | 0.83 | TDP1 (0.46) | TDP1KDM4EMAPT | |
| Propylene Glycol SCHEMBL28578 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3936375-A | Process for dewatering a proteinaceous, aqueous sludge and for removing and recovering precipitating agents from a precipitate containing proteinaceous substances | A/S APOTHEKERNES LABORATORIUM FOR SPECIALPRAEPARATER (NO) | 1976-02-03 | — | — | US | disclosed |