Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.82 |
| ▸ | CDK2 | P24941 | 13/20 | 0.82 |
| ▸ | CDK9 | P50750 | 13/20 | 0.82 |
| ▸ | CDK1 | P06493 | 13/20 | 0.82 |
| ▸ | CCND1 | P24385 | 12/20 | 0.82 |
| ▸ | CCNT1 | O60563 | 11/20 | 0.82 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.82 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.82 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.82 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.82 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.82 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.82 |
| ▸ | CCND3 | P30281 | 4/20 | 0.82 |
| ▸ | GSK3A | P49840 | 4/20 | 0.82 |
| ▸ | CDK7 | P50613 | 3/20 | 0.82 |
| ▸ | CCNH | P51946 | 2/20 | 0.82 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.82 |
| ▸ | MAPK15 | Q8TD08 | 2/20 | 0.82 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.82 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6519994 | 1.00 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| SCHEMBL1180644 | 1.00 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| SCHEMBL1180211 | 0.93 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| SCHEMBL2440058 | 0.93 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| SCHEMBL1180213 | 0.93 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| SCHEMBL2440062 | 0.93 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| SCHEMBL2440055 | 0.93 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| SCHEMBL1180222 | 0.93 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| Hydrochloric Acid SCHEMBL1180102 | 0.92 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 | |
| Hydrochloric Acid SCHEMBL2441417 | 0.92 | CDK4 (0.82) | CDK4CDK2CDK9CDK1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884127-B2 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | Pirimal Life Sciences Ltd. (IN) | 2011-02-08 | — | — | US | claimed |
| US-20070015802-A1 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2007-01-18 | — | — | US | claimed |
| US-20130045993-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES AND THEIR USE | Piramal Enterprises Limited (IN) | 2013-02-21 | — | — | US | disclosed |
| US-8304449-B2 | Inhibitors of cyclin dependent kinases and their use | PIRAMAL HEALTHCARE LIMITED (IN) | 2012-11-06 | — | — | US | disclosed |
| US-20110136873-A1 | Inhibitors of Cyclin Dependent Kinases and Their Use | PIRAMAL LIFE SCIENCES LTD. (IN) | 2011-06-09 | — | — | US | disclosed |
| US-7884127-B2 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | Pirimal Life Sciences Ltd. (IN) | 2011-02-08 | — | — | US | disclosed |
| US-20070015802-A1 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2007-01-18 | — | — | US | disclosed |
| US-20040106581-A1 | Inhibitors of cyclin-dependent kinases and their use | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106581-A1 | Inhibitors of cyclin-dependent kinases and their use | CCNK, CCNI, CDK1 | CDK4 8/4885CDK2 4/4885CDK9 35/4885 |
| US-20110136873-A1 | Inhibitors of Cyclin Dependent Kinases and Their Use | CDK1, CCNK, CCNI | CDK4 11/4885CDK2 4/4885CDK9 43/4885 |
| US-20130045993-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES AND THEIR USE | CDK1, CCNK, CCNI | CDK4 7/4885CDK2 4/4885CDK9 38/4885 |
| US-20070015802-A1 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | CCNI, CDK1, CCNA1 | CDK4 7/4885CDK2 6/4885CDK9 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.