Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11804290 | 0.84 | TSHR (0.47) | TSHRBRD4CYP1B1ALDH1A1KDM4E | |
| SCHEMBL11852039 | 0.81 | TSHR (0.62) | TSHRALDH1A1GAAGFERLMNA | |
| SCHEMBL11803846 | 0.81 | TSHR (0.45) | TSHRALDH1A1GAAGFERLMNA | |
| SCHEMBL11802928 | 0.81 | TSHR (0.59) | TSHRBRD4ACHEDRD2ALDH1A1 | |
| SCHEMBL11807924 | 0.79 | TSHR (0.43) | TSHRBRD4ALDH1A1LMNA | |
| SCHEMBL11806517 | 0.79 | TSHR (0.43) | TSHRDPP4FAPALDH1A1GAA | |
| SCHEMBL11806199 | 0.79 | TSHR (0.69) | TSHRBRD4GAAGFERLMNA | |
| SCHEMBL11802972 | 0.78 | MEN1 (0.54) | TSHRDRD2HTR2AALDH1A1LMNA | |
| SCHEMBL11803813 | 0.78 | TSHR (0.56) | TSHRALDH1A1GAAGFERLMNA | |
| SCHEMBL11800225 | 0.78 | CYP1A2 (0.56) | TSHRKDM4EGAAGFERLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3975386-A | PYRIDOPYRIMIDINE-ONE INTERMEDIATES | SANDOZ, INC. (US) | 1976-08-17 | — | — | US | disclosed |