⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099559 | 0.76 | — | — | |
| SCHEMBL4607074 | 0.74 | — | — | |
| SCHEMBL3432940 | 0.74 | — | — | |
| SCHEMBL1180970 | 0.74 | — | — | |
| SCHEMBL1180079 | 0.74 | — | — | |
| SCHEMBL1180081 | 0.74 | — | — | |
| SCHEMBL3432939 | 0.74 | — | — | |
| SCHEMBL3431780 | 0.69 | — | — | |
| SCHEMBL16703165 | 0.69 | — | — | |
| SCHEMBL317518 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112592335-A | Carbazole isopropanol diamine compound containing 1, 2, 3-triazole and preparation method and application thereof | 贵州大学 | 2021-04-02 | — | — | CN | claimed |
| US-8148537-B2 | Substituted acetophenones useful as PDE4 inhibitors | LEO PHARMA A/S (DK) | 2012-04-03 | — | — | US | claimed |
| CN-112624962-B | Carbazolyl isopropanolamine derivatives with double chiral centers and preparation method and application thereof | 贵州大学 | 2023-03-31 | — | — | CN | disclosed |
| US-20220160908-A1 | CHELATORS AND METHODS OF MAKING AND USING SAME | PROVINCIAL HEALTH SERVICES AUTHORITY (CA) | 2022-05-26 | — | — | US | disclosed |
| CN-112592335-A | Carbazole isopropanol diamine compound containing 1, 2, 3-triazole and preparation method and application thereof | 贵州大学 | 2021-04-02 | — | — | CN | disclosed |
| WO-2020186328-A1 | CHELATORS AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2020-09-24 | — | — | WO | disclosed |
| US-20130045993-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES AND THEIR USE | Piramal Enterprises Limited (IN) | 2013-02-21 | — | — | US | disclosed |
| US-8304449-B2 | Inhibitors of cyclin dependent kinases and their use | PIRAMAL HEALTHCARE LIMITED (IN) | 2012-11-06 | — | — | US | disclosed |
| US-20110136873-A1 | Inhibitors of Cyclin Dependent Kinases and Their Use | PIRAMAL LIFE SCIENCES LTD. (IN) | 2011-06-09 | — | — | US | disclosed |
| US-7915301-B2 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one | Piramal Life Science Limited (IN) | 2011-03-29 | — | — | US | disclosed |
| US-7884127-B2 | chromenone derivatives of nitrogen-, oxygen- or sulfur-containing saturated heterocycles; preparation by cyclizing benzoyl intermediates; antiproliferative agents; 2-(2-Chloro-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one; acidification | Pirimal Life Sciences Ltd. (IN) | 2011-02-08 | — | — | US | disclosed |
| WO-2004004632-A2 | FLAVONE DERIVATIVES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2004-01-15 | — | — | WO | disclosed |
| EP-1341766-A1 | IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-10 | — | — | EP | disclosed |
| US-20030069276-A1 | Amino piperidine derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 2003-04-10 | — | — | US | disclosed |
| US-6538015-B1 | Process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is | HOFFMANN-LA ROCHE INC. | 2003-03-25 | — | — | US | disclosed |
| US-6518293-B2 | Inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. | HOFFMANN-LA ROCHE INC. | 2003-02-11 | — | — | US | disclosed |
| WO-2002100853-A1 | PYRAZOLE DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-12-19 | — | — | WO | disclosed |
| WO-2002079186-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-10 | — | — | WO | disclosed |
| US-20020107272-A1 | Anti-HIV imidazolone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | US | disclosed |
| WO-2002042279-A1 | IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-30 | — | — | WO | disclosed |