Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | ME2 | P23368 | 1/20 | 0.48 |
| ▸ | ME1 | P48163 | 1/20 | 0.48 |
| ▸ | ME3 | Q16798 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11828818 | 0.84 | TSHR (0.57) | POLBHPGDSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8414684 | 0.81 | NPC1 (0.65) | POLBNPC1TDP1FKBP1AHPGD | |
| SCHEMBL8411392 | 0.81 | NPC1 (0.65) | POLBNPC1TDP1FKBP1AHPGD | |
| SCHEMBL2132589 | 0.78 | NPC1 (0.66) | POLBNPC1TDP1FKBP1AHPGD | |
| SCHEMBL2135979 | 0.78 | NPC1 (0.61) | POLBNPC1TDP1FKBP1AHPGD | |
| SCHEMBL7131839 | 0.77 | NPC1 (0.86) | POLBNPC1TDP1FKBP1AHPGD | |
| SCHEMBL6289171 | 0.76 | POLB (0.77) | POLBNPC1TDP1FKBP1AHPGD | |
| SCHEMBL12945058 | 0.76 | POLB (0.67) | POLBNPC1TDP1FKBP1AHPGD | |
| SCHEMBL4704100 | 0.75 | POLB (0.75) | POLBNPC1TDP1FKBP1AHPGD | |
| SCHEMBL4704483 | 0.74 | POLB (0.73) | POLBNPC1TDP1FKBP1AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015109451-A1 | SYNTHESIS OF COMPOUNDS CONTAINING 8-OXA-3-AZABICYCLO (3.2.1)OCTANE RING | RHODIA OPERATIONS (FR) | 2015-07-30 | — | — | WO | disclosed |
| US-3953596-A | 8-Oxa-3-azabicyclo(3.2.1)octane analgesic compositions and method of alleviating pain in animals | ICI UNITED STATES INC. (US) | 1976-04-27 | — | — | US | disclosed |