Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11865925 | 0.99 | RAD52 (0.63) | RAD52TP53MAPTRAB9AHPGD | |
| SCHEMBL11857626 | 0.94 | RAD52 (0.57) | RAD52TP53MAPTRAB9AHPGD | |
| Hydrochloric Acid SCHEMBL11867166 | 0.91 | RAD52 (0.74) | RAD52TP53MAPTRAB9AHPGD | |
| Hydrochloric Acid SCHEMBL11864379 | 0.91 | RAD52 (0.56) | RAD52TP53MAPTRAB9AHPGD | |
| Fumaric Acid SCHEMBL11862246 | 0.90 | RAD52 (0.53) | RAD52TP53MAPTRAB9AHPGD | |
| Maleic Acid SCHEMBL11862236 | 0.90 | RAD52 (0.53) | RAD52TP53MAPTRAB9AHPGD | |
| SCHEMBL11859430 | 0.89 | RAD52 (0.75) | RAD52TP53MAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11854978 | 0.88 | RAD52 (0.74) | RAD52TP53MAPTHPGDSMN1; SMN2 | |
| Iodomethane SCHEMBL11870131 | 0.87 | RAD52 (0.73) | RAD52TP53MAPTHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11868391 | 0.87 | RAD52 (0.63) | RAD52TP53MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3940418-A | Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds | G. D. SEARLE & CO. (US) | 1976-02-24 | — | — | US | claimed |
| US-3940418-A | Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds | G. D. SEARLE & CO. (US) | 1976-02-24 | — | — | US | disclosed |