Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.59 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.59 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.59 |
| ▸ | FAP | Q12884 | 1/20 | 0.59 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.59 |
| ▸ | ACE | P12821 | 4/20 | 0.50 |
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11865608 | 1.00 | DPP4 (0.59) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL29356868 | 0.98 | DPP4 (0.60) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL27902671 | 0.98 | DPP4 (0.60) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL29565533 | 0.98 | DPP4 (0.60) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL825679 | 0.98 | DPP4 (0.60) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL30924754 | 0.98 | DPP4 (0.60) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL6371844 | 0.98 | DPP4 (0.60) | DPP4DPP8DPP9FAPDPP7 | |
| Hydrochloric Acid SCHEMBL29415382 | 0.97 | DPP4 (0.59) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL10658318 | 0.97 | DPP4 (0.59) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL10658327 | 0.97 | DPP4 (0.59) | DPP4DPP8DPP9FAPDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3973006-A | Peptide enzyme inhibitors of angiotensin I | E. R. SQUIBB & SONS, INC. (US) | 1976-08-03 | — | — | US | disclosed |