Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 16/20 | 0.82 |
| ▸ | KDR | P35968 | 13/20 | 0.82 |
| ▸ | BRAF | P15056 | 9/20 | 0.82 |
| ▸ | LCK | P06239 | 8/20 | 0.82 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264176 | 0.90 | TEK (1.00) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL11889229 | 0.89 | TEK (0.69) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL2261523 | 0.86 | TEK (0.79) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL4792941 | 0.83 | TEK (0.83) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL11889277 | 0.83 | TEK (0.79) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL2515742 | 0.81 | TEK (0.72) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL2517827 | 0.81 | TEK (0.77) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL11889124 | 0.81 | BRAF (1.00) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL2261239 | 0.80 | TEK (0.76) | TEKKDRBRAFLCKMAPK14 | |
| SCHEMBL2262420 | 0.79 | TEK (0.73) | TEKKDRBRAFLCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2481729-A1 | Nintrogen-containing bicyclic heteroaryl compounds for the treatment of RAF protein kinase-mediated diseases | Amgen Inc. (US) | 2012-08-01 | — | — | EP | disclosed |