Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.75 |
| ▸ | KDR | P35968 | 8/20 | 0.75 |
| ▸ | LCK | P06239 | 7/20 | 0.75 |
| ▸ | TEK | Q02763 | 7/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.66 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889333 | 0.91 | BRAF (0.74) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL11889023 | 0.90 | BRAF (0.83) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL11889300 | 0.90 | BRAF (0.83) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL2516061 | 0.88 | TEK (0.74) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL2514587 | 0.87 | BRAF (0.82) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL11889317 | 0.87 | TEK (0.79) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL2517955 | 0.86 | BRAF (1.00) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL11889205 | 0.86 | BRAF (0.78) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL11889511 | 0.85 | BRAF (0.83) | BRAFKDRLCKTEKMAPK14 | |
| SCHEMBL11888951 | 0.83 | BRAF (0.84) | BRAFKDRLCKTEKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976836-B9 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF RAF PROTEIN KINASE-MEDIATED DISEASES | AMGEN INC (US) | 2013-02-06 | — | — | EP | disclosed |
| EP-1976836-B1 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF RAF PROTEIN KINASE-MEDIATED DISEASES | AMGEN INC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2481729-A1 | Nintrogen-containing bicyclic heteroaryl compounds for the treatment of RAF protein kinase-mediated diseases | Amgen Inc. (US) | 2012-08-01 | — | — | EP | disclosed |