Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.53 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.47 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 5/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889301 | 0.95 | LCK (0.53) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL11889081 | 0.93 | BRAF (0.55) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL11889202 | 0.93 | BRAF (0.55) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL11889497 | 0.93 | LCK (0.51) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL2263907 | 0.90 | BRAF (0.60) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL11889121 | 0.90 | LCK (0.56) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL11889057 | 0.89 | LCK (0.58) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL11888979 | 0.89 | LCK (0.48) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL11889296 | 0.88 | LCK (0.53) | LCKBRAFKDRMAPK14TEK | |
| SCHEMBL11889389 | 0.88 | LCK (0.52) | LCKBRAFKDRMAPK14TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976836-B9 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF RAF PROTEIN KINASE-MEDIATED DISEASES | AMGEN INC (US) | 2013-02-06 | — | — | EP | disclosed |
| EP-1976836-B1 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS FOR THE TREATMENT OF RAF PROTEIN KINASE-MEDIATED DISEASES | AMGEN INC (US) | 2012-08-22 | — | — | EP | disclosed |
| EP-2481729-A1 | Nintrogen-containing bicyclic heteroaryl compounds for the treatment of RAF protein kinase-mediated diseases | Amgen Inc. (US) | 2012-08-01 | — | — | EP | disclosed |