Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 20/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 16/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322018 | 0.94 | DYRK1A (0.61) | DYRK1ADYRK1B | |
| SCHEMBL11951534 | 0.88 | DYRK1A (0.67) | DYRK1ADYRK1B | |
| SCHEMBL10322496 | 0.87 | DYRK1A (0.55) | DYRK1ADYRK1B | |
| SCHEMBL10323165 | 0.85 | DYRK1A (0.65) | DYRK1ADYRK1B | |
| SCHEMBL10323802 | 0.83 | DYRK1A (0.78) | DYRK1ADYRK1B | |
| SCHEMBL11949604 | 0.83 | DYRK1A (0.78) | DYRK1ADYRK1B | |
| SCHEMBL10323803 | 0.83 | DYRK1A (0.78) | DYRK1ADYRK1B | |
| SCHEMBL10321795 | 0.83 | DYRK1A (0.66) | DYRK1ADYRK1B | |
| SCHEMBL11952007 | 0.82 | DYRK1A (0.72) | DYRK1ADYRK1B | |
| SCHEMBL10322778 | 0.82 | DYRK1A (0.76) | DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098066-A1 | 1,6- AND 1,8-NAPHTHYRIDINES USEFUL AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |