Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.56 |
| ▸ | KDR | P35968 | 3/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.51 |
| ▸ | P2RY1 | P47900 | 6/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1264047 | 0.80 | KDR (0.57) | BRAFKDRTRPV1TEKABL1 | |
| SCHEMBL15147774 | 0.78 | KDR (0.54) | BRAFKDRTRPV1NTRK1TEK | |
| SCHEMBL1264938 | 0.78 | KDR (0.81) | BRAFKDRTEKABL1AURKA | |
| SCHEMBL29071535 | 0.78 | DDR2 (0.69) | BRAFKDRNTRK1TEKABL1 | |
| SCHEMBL1264796 | 0.77 | TEK (0.66) | BRAFKDRTEKABL1AURKA | |
| SCHEMBL11896921 | 0.75 | AURKB (0.64) | KDRAURKAAURKBTPX2 | |
| Trifluoroacetic Acid SCHEMBL3342945 | 0.73 | — | — | |
| SCHEMBL1264618 | 0.73 | TEK (0.74) | BRAFKDRTEKABL1AURKA | |
| SCHEMBL15141110 | 0.73 | KDR (0.68) | BRAFKDRTRPV1ABL1AURKA | |
| SCHEMBL1265692 | 0.73 | TEK (0.75) | BRAFKDRTRPV1TEKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236823-B2 | Multi-cyclic compounds and methods of use | AMGEN INC. (US) | 2012-08-07 | — | — | US | claimed |