Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.56 |
| ▸ | MTOR | P42345 | 6/20 | 0.54 |
| ▸ | ATR | Q13535 | 13/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 11/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 11/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.47 |
| ▸ | ATRIP | Q8WXE1 | 10/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600869 | 1.00 | PIK3CA (0.56) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3594078 | 0.83 | PIK3CA (0.55) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3095567 | 0.82 | PIK3CA (0.60) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3609460 | 0.82 | PIK3CA (0.66) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3597306 | 0.81 | PIK3CA (0.53) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3606998 | 0.81 | PIK3CA (0.58) | PIK3CAPIK3CDMTOR | |
| SCHEMBL11898434 | 0.80 | PIK3CA (0.55) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3598799 | 0.80 | PIK3CA (0.55) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3600934 | 0.79 | PIK3CA (0.58) | PIK3CAPIK3CDMTORATRPDCD1 | |
| SCHEMBL3597515 | 0.79 | PIK3CA (0.49) | PIK3CAPIK3CDMTORATRPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |