Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tamoxifen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 14/20 | 0.97 |
| ▸ | ESRRG | P62508 | 8/20 | 0.97 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.97 |
| ▸ | MAPT | P10636 | 3/20 | 0.97 |
| ▸ | ESRRB | O95718 | 3/20 | 0.97 |
| ▸ | MEN1 | O00255 | 2/20 | 0.97 |
| ▸ | TP53 | P04637 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.97 |
| ▸ | PGR | P06401 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | PLD2 | O14939 | 1/20 | 0.97 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.97 |
| ▸ | NPC1 | O15118 | 1/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.88 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Afimoxifene SCHEMBL640496 | 0.99 | ESR1 (1.00) | ESR1ESRRGESR2MAPTESRRB | |
| Afimoxifene SCHEMBL2132301 | 0.99 | ESR1 (1.00) | ESR1ESRRGESR2MAPTESRRB | |
| SCHEMBL2165503 | 0.99 | ESR1 (1.00) | ESR1ESRRGESR2MAPTESRRB | |
| SCHEMBL15668666 | 0.99 | ESR1 (1.00) | ESR1ESRRGESR2MAPTESRRB | |
| Afimoxifene SCHEMBL9189 | 0.99 | ESR1 (1.00) | ESR1ESRRGESR2MAPTESRRB | |
| Tamoxifen SCHEMBL9121934 | 0.96 | ESR1 (0.95) | ESR1ESRRGESR2MAPTESRRB | |
| Afimoxifene SCHEMBL7649812 | 0.94 | ESR1 (0.91) | ESR1ESRRGESR2MAPTESRRB | |
| Afimoxifene SCHEMBL7649806 | 0.94 | ESR1 (0.91) | ESR1ESRRGESR2MAPTESRRB | |
| SCHEMBL9857247 | 0.94 | ESR1 (0.90) | ESR1ESRRGESR2MAPTESRRB | |
| SCHEMBL9857240 | 0.94 | ESR1 (0.90) | ESR1ESRRGESR2MAPTESRRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202215-A1 | MITOCHONDRIAL FUNCTION OF PROHIBITIN 2 (PHB2) | JICHI MEDICAL UNIVERSITY (JP) | 2012-08-09 | — | — | US | claimed |
| EP-3638320-A2 | IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF | Fusion Pharmaceuticals Inc. (CA) | 2020-04-22 | — | — | EP | disclosed |
| EP-3619191-A1 | PHARMACOKINETIC ENHANCEMENTS OF BIFUNCTIONAL CHELATES AND USES THEREOF | Fusion Pharmaceuticals Inc. (CA) | 2020-03-11 | — | — | EP | disclosed |
| WO-2018204872-A2 | IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF | Fusion Pharmaceuticals Inc. (CA) | 2018-11-08 | — | — | WO | disclosed |
| WO-2018204869-A1 | PHARMACOKINETIC ENHANCEMENTS OF BIFUNCTIONAL CHELATES AND USES THEREOF | Fusion Pharmaceuticals Inc. (CA) | 2018-11-08 | — | — | WO | disclosed |
| WO-2018160178-A1 | PHARMACEUTICALLY ACCEPTABLE SALTS OF B-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF | RGENIX, INC. (US) | 2018-09-07 | — | — | WO | disclosed |
| EP-3340973-A1 | PHARMACEUTICALLY ACCEPTABLE SALTS OF -GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF | Rgenix, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |
| EP-3137447-A1 | INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF | Rgenix, Inc. (US) | 2017-03-08 | — | — | EP | disclosed |
| WO-2017035331-A1 | PHARMACEUTICALLY ACCEPTABLE SALTS OF β-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF | RGENIX, INC. (US) | 2017-03-02 | — | — | WO | disclosed |
| WO-2016176636-A1 | INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF | RGENIX, INC. (US) | 2016-11-03 | — | — | WO | disclosed |
| WO-2015168465-A1 | INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF | RGENIX, INC. (US) | 2015-11-05 | — | — | WO | disclosed |