SCHEMBL11904841

SCHEMBL11904841

CCCCCn1c(Sc2cc3c(cc2-c2ncc(C)o2)OCCO3)nc2c(N)ncnc21

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 14/20 0.50
HSP90AB1 P08238 13/20 0.50
ERBB2 P04626 4/20 0.49
TRAP1 Q12931 4/20 0.49
HSP90B1 P14625 3/20 0.49
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1670451 0.90 HSP90AA1 (0.56) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL1672507 0.89 HSP90AB1 (0.48) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL11908574 0.88 HSP90AB1 (0.53) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL1670077 0.88 HSP90AB1 (0.56) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL11908764 0.87 HSP90AA1 (0.50) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL18203347 0.86 HSP90AB1 (0.54) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL1669515 0.85 HSP90AA1 (0.61) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL1669501 0.84 HSP90AB1 (0.53) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL1670005 0.83 HSP90AA1 (0.57) HSP90AA1HSP90AB1ERBB2TRAP1HSP90B1
SCHEMBL11909083 0.83 HSP90AA1 (0.49) HSP90AA1HSP90AB1HDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2486039-A1 PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS Sloan Kettering Institute For Cancer Research (US) 2012-08-15 EP claimed