SCHEMBL11904879

SCHEMBL11904879

CC(C)NCCCn1c(Sc2cc3c(cc2-c2ccc(CN)o2)OCO3)nc2c(Nc3ccccc3)ncnc21

nearest known ligand 0.55

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 15/20 0.55
HSP90AB1 P08238 10/20 0.55
HSP90B1 P14625 5/20 0.55
TRAP1 Q12931 5/20 0.55
ERBB2 P04626 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1671728 0.89 HSP90AA1 (0.52) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL1670004 0.88 HSP90AA1 (0.70) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL1669419 0.80 HSP90AA1 (0.72) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL1669632 0.79 HSP90AA1 (0.78) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL17770990 0.78 HSP90AA1 (0.69) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL1670412 0.77 HSP90AA1 (0.68) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL1669663 0.77 HSP90AA1 (0.72) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL1669789 0.75 HSP90AA1 (0.65) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL17770976 0.75 HSP90AA1 (0.69) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL1672906 0.75 HSP90AA1 (0.71) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2486039-A1 PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS Sloan Kettering Institute For Cancer Research (US) 2012-08-15 EP disclosed