Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.58 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.58 |
| ▸ | TRAP1 | Q12931 | 6/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11908481 | 0.97 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL1670252 | 0.91 | HSP90AA1 (0.65) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL11903645 | 0.89 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL1669231 | 0.88 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL1669663 | 0.88 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL18203394 | 0.88 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL11908304 | 0.88 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL11908178 | 0.88 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL18203356 | 0.87 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 | |
| SCHEMBL18203295 | 0.86 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1HSP90B1ERBB2TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091019-B1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | SLOAN KETTERING INST CANCER RES (US) | 2019-04-03 | — | — | EP | disclosed |
| EP-3091019-A2 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | Sloan Kettering Institute For Cancer Research (US) | 2016-11-09 | — | — | EP | disclosed |
| US-9328114-B2 | Hsp90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2016-05-03 | — | — | US | disclosed |
| US-20120208806-A1 | Hsp90 Inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208806-A1 | Hsp90 Inhibitors | HSP90B1, HSP90AB1, HSP90AB2P | HSP90AA1 4/4885HSP90AB1 2/4885HSP90B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.