Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.63 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.46 |
| ▸ | TUBB | P07437 | 6/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13554947 | 0.96 | SRC (0.63) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12301518 | 0.93 | SRC (0.53) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13553757 | 0.91 | SRC (0.61) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL23761852 | 0.91 | SRC (0.63) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11920224 | 0.89 | SRC (0.63) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2814508 | 0.89 | SRC (0.56) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11917538 | 0.87 | SRC (0.69) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL11917537 | 0.86 | SRC (0.60) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL10169058 | 0.86 | SRC (0.70) | SRCTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19291803 | 0.86 | SRC (0.69) | SRCTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170196874-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | OAKTREE FUND ADMINISTRATION, LLC | 2017-07-13 | — | — | US | disclosed |
| US-9580387-B2 | Biaryl compositions and methods for modulating a kinase cascade | ATHENEX, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20140213587-A1 | Biaryl Compositions and Methods for Modulating a Kinase Cascade | KINEX PHARMACEUTICALS, LLC (US) | 2014-07-31 | — | — | US | disclosed |
| US-8748423-B2 | Compositions and methods for the prevention and treatment of cancer | KINEX PHARMACEUTICALS, LLC (US) | 2014-06-10 | — | — | US | disclosed |
| US-8236799-B2 | Biaryl compositions and methods for modulating a kinase cascade | KINEX PHARMACEUTICALS, LLC (US) | 2012-08-07 | — | — | US | disclosed |
| US-20110281872-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER | KINEX PHARMACEUTICALS, LLC (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110237586-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS, LLC (US) | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213587-A1 | Biaryl Compositions and Methods for Modulating a Kinase Cascade | MAP3K3, MAP3K2, MAP3K20 | SRC 76/4885TUBB4A 2391/4885TUBB 2092/4885 |
| US-20170196874-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | MAP3K3, MAP3K2, MAP3K20 | SRC 76/4885TUBB4A 2391/4885TUBB 2092/4885 |
| US-20110237586-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | BMP2K, MAP3K1, MAP3K20 | SRC 106/4885TUBB4A 1668/4885TUBB 1061/4885 |
| US-20110281872-A1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER | TP53, MKI67, BRCA1 | SRC 516/4885TUBB4A 463/4885TUBB 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.