⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9912326 | 1.00 | — | — | |
| SCHEMBL13696402 | 1.00 | — | — | |
| SCHEMBL12389152 | 0.86 | — | — | |
| SCHEMBL13696396 | 0.85 | — | — | |
| SCHEMBL9912323 | 0.85 | — | — | |
| SCHEMBL11924456 | 0.85 | — | — | |
| SCHEMBL13392130 | 0.78 | — | — | |
| SCHEMBL9912342 | 0.77 | HIF1A (0.32) | — | |
| SCHEMBL13696397 | 0.77 | HIF1A (0.32) | — | |
| SCHEMBL9912340 | 0.77 | HIF1A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155758-B1 | TETRAHYDROFURO[3,4-D]DIOXOLANE COMPOUNDS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS AND CANCER | BIOCRYST PHARM INC (US) | 2012-08-22 | — | — | EP | disclosed |
| US-8242085-B2 | Tetrahydrofuro [3,4-D] dioxolane compounds for use in the treatment of viral infections and cancer | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-20110002886-A1 | TETRAHYDROFURO [3,4-D] DIOXOLANE COMPOUNDS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS AND CANCER | BIOCRYST PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| WO-2008141079-A1 | TETRAHYDROFURO [3 4-D] DIOXOLANE COMPOUNDS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS AND CANCER | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-11-20 | — | — | WO | disclosed |