Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.44 |
| ▸ | SUV39H2 | Q9H5I1 | 8/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050804 | 0.92 | SUV39H2 (0.43) | PDE10ASUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL11931288 | 0.89 | PDE10A (0.42) | PDE10ASUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL11931287 | 0.86 | CKS1B (0.49) | PDE10ASUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL14050863 | 0.83 | SUV39H2 (0.49) | PDE10ASUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL14050865 | 0.82 | PDE10A (0.43) | PDE10ASUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL14050907 | 0.81 | SUV39H2 (0.40) | PDE10ASUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL14051088 | 0.79 | SUV39H2 (0.39) | PDE10ASUV39H2CKS1BSKP1SKP2 | |
| SCHEMBL14413671 | 0.78 | SUV39H2 (0.48) | PDE10ASUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL14050999 | 0.78 | SUV39H2 (0.48) | PDE10ASUV39H2MAP4K4CKS1BSKP1 | |
| SCHEMBL14050871 | 0.77 | NPC1 (0.40) | PDE10ASUV39H2MAP4K4CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942900-B1 | USE OF PYRAZOLO [1,5-A] PYRIMIDINE DERIVATIVES FOR INHIBITING KINASES METHODS FOR INHIBITING PROTEIN KINASES | MERCK SHARP & DOHME (US) | 2015-06-03 | — | — | EP | disclosed |
| US-8211854-B2 | Methods for inhibiting protein kinases | SCHERING CORPORATION (US) | 2012-07-03 | — | — | US | disclosed |
| US-8211854-B2 | Methods for inhibiting protein kinases | SCHERING CORPORATION (US) | 2012-07-03 | — | — | US | disclosed |
| US-7776865-B2 | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2010-08-17 | — | — | US | disclosed |
| US-7776865-B2 | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2010-08-17 | — | — | US | disclosed |
| US-20100125068-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION | 2010-05-20 | — | — | US | disclosed |
| US-20100125068-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION | 2010-05-20 | — | — | US | disclosed |
| US-20070082900-A1 | Methods for inhibiting protein kinases | SCHERING CORPORATION | 2007-04-12 | — | — | US | disclosed |
| US-20070083044-A1 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082900-A1 | Methods for inhibiting protein kinases | PIM1, AURKC, PIM3 | PDE10A 2927/4885SUV39H2 2004/4885MAP4K4 69/4885 |
| US-20070083044-A1 | Pyrazolopyrimidines as protein kinase inhibitors | CHEK1, CHEK2, BUB1 | PDE10A 1963/4885SUV39H2 3046/4885MAP4K4 54/4885 |
| US-20100125068-A1 | METHODS FOR INHIBITING PROTEIN KINASES | PIM1, AURKC, PIM3 | PDE10A 2927/4885SUV39H2 2004/4885MAP4K4 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.