Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 12/20 | 0.47 |
| ▸ | MAPT | P10636 | 11/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 8/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11941163 | 1.00 | GAA (0.47) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL13105592 | 1.00 | GAA (0.47) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL11936069 | 1.00 | GAA (0.47) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL13462817 | 0.85 | MAPT (0.51) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL13113501 | 0.85 | MAPT (0.51) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL11935859 | 0.85 | MAPT (0.51) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL11935903 | 0.85 | MAPT (0.51) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL6608413 | 0.82 | MAPT (0.48) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL13716676 | 0.82 | MAPT (0.48) | GAAMAPTKDM4EL3MBTL1ALOX12 | |
| SCHEMBL11936094 | 0.79 | GAA (0.50) | GAAMAPTKDM4EL3MBTL1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150507-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-9150507-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-8227618-B2 | Amine-derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-07-24 | — | — | US | disclosed |
| US-20100273841-A1 | AMINE-DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2010-10-28 | — | — | US | disclosed |
| US-20100063027-A1 | Amine Derivative Having NPY Y5 Receptor Antagonistic Activity | SHIONOGI & CO., LTD. (JP) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063027-A1 | Amine Derivative Having NPY Y5 Receptor Antagonistic Activity | NPY5R, NPY1R, NPY2R | GAA 4212/4885MAPT 3293/4885KDM4E 1765/4885 |
| US-20100273841-A1 | AMINE-DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF | NPY5R, NPY1R, NPY2R | GAA 2277/4885MAPT 4321/4885KDM4E 1334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.