Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12934705 | 0.93 | KCNH2 (0.61) | CHRM4CHRM1KCNH2SIGMAR1 | |
| SCHEMBL11939158 | 0.90 | KCNH2 (0.59) | CHRM4CHRM1KCNH2SIGMAR1 | |
| SCHEMBL12935156 | 0.89 | KCNH2 (0.56) | CHRM4CHRM1KCNH2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL1747772 | 0.89 | KCNH2 (0.58) | CHRM4CHRM1KCNH2SIGMAR1 | |
| SCHEMBL12934764 | 0.89 | KCNH2 (0.58) | CHRM4CHRM1KCNH2SIGMAR1 | |
| SCHEMBL12934866 | 0.89 | KCNH2 (0.59) | CHRM4CHRM1KCNH2SIGMAR1 | |
| SCHEMBL12935242 | 0.88 | KCNH2 (0.56) | CHRM4CHRM1KCNH2SIGMAR1 | |
| SCHEMBL11939645 | 0.88 | KCNH2 (0.57) | CHRM4CHRM1KCNH2SIGMAR1 | |
| SCHEMBL12934982 | 0.87 | KCNH2 (0.56) | CHRM4CHRM1KCNH2SIGMAR1 | |
| SCHEMBL12934903 | 0.87 | KCNH2 (0.56) | CHRM4CHRM1KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817036-B1 | MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMA (US) | 2012-07-04 | — | — | EP | disclosed |
| US-7863449-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863449-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-04 | — | — | US | disclosed |