Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 13/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11959420 | 0.97 | SCNN1A (0.62) | SCNN1AKCNH2 | |
| SCHEMBL12379802 | 0.94 | SCNN1A (0.59) | SCNN1AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL1434747 | 0.93 | SCNN1A (0.57) | SCNN1AKCNH2 | |
| SCHEMBL11959422 | 0.90 | SCNN1A (0.62) | SCNN1AKCNH2 | |
| SCHEMBL11959474 | 0.90 | KCNH2 (0.60) | SCNN1AKCNH2 | |
| SCHEMBL13573293 | 0.88 | SCNN1A (0.60) | SCNN1AKCNH2 | |
| SCHEMBL11959456 | 0.88 | KCNH2 (0.58) | SCNN1AKCNH2 | |
| SCHEMBL11959329 | 0.88 | SCNN1A (0.60) | SCNN1AKCNH2 | |
| Bromide SCHEMBL2287891 | 0.87 | SCNN1A (0.59) | SCNN1AKCNH2 | |
| Bromide SCHEMBL1428109 | 0.87 | SCNN1A (0.59) | SCNN1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236808-B2 | Pyrazine derivatives as ENAC blockers | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | disclosed |