Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.54 |
| ▸ | CTSV | O60911 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MDH2 | P40926 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479759 | 0.89 | JAK2 (0.67) | IKBKEJAK2MAOAMAOBSMN1; SMN2 | |
| SCHEMBL627903 | 0.88 | TTK (0.59) | IKBKECTSVCTSLJAK2MAOA | |
| SCHEMBL13736995 | 0.88 | FLT3 (0.55) | JAK2FLT3 | |
| SCHEMBL6479373 | 0.87 | JAK2 (0.63) | IKBKEJAK2MAOBTTKGSK3B | |
| SCHEMBL18640073 | 0.86 | IKBKE (0.43) | IKBKECTSVCTSLJAK2MAOA | |
| SCHEMBL216014 | 0.86 | CNR2 (0.54) | IKBKEJAK2MAOBRAB9A | |
| SCHEMBL18639944 | 0.86 | MAOB (0.47) | IKBKEJAK2MAOAFLT3MAOB | |
| SCHEMBL18639883 | 0.86 | MAOB (0.49) | JAK2MAOAMAOBHPGD | |
| SCHEMBL18640103 | 0.85 | MAOB (0.55) | MAOAMAOB | |
| SCHEMBL6479517 | 0.84 | JAK2 (0.50) | IKBKEJAK2MAPTTTKPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045751-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |
| EP-2489663-A1 | Compounds as syk kinase inhibitors | Almirall, S.A. (ES) | 2012-08-22 | — | — | EP | disclosed |