Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11963801 | 1.00 | HDAC1 (0.43) | HDAC1PARP1MAPK8GPR119JAK2 | |
| SCHEMBL11963126 | 0.91 | PARP1 (0.43) | HDAC1PARP1MAPK8GPR119JAK2 | |
| SCHEMBL11963125 | 0.91 | PARP1 (0.43) | HDAC1PARP1MAPK8GPR119JAK2 | |
| SCHEMBL11963110 | 0.90 | MAPK8 (0.41) | HDAC1PARP1MAPK8GPR119JAK2 | |
| SCHEMBL11963162 | 0.90 | HDAC1 (0.41) | HDAC1PARP1MAPK8GPR119JAK2 | |
| SCHEMBL11963365 | 0.89 | HDAC1 (0.33) | HDAC1JAK2JAK1IGF1RRAB9A | |
| SCHEMBL11963337 | 0.88 | MAPK8 (0.42) | HDAC1PARP1MAPK8GPR119JAK2 | |
| SCHEMBL11963133 | 0.88 | MAPK8 (0.38) | HDAC1PARP1MAPK8GPR119JAK2 | |
| SCHEMBL11963307 | 0.85 | MAPK8 (0.40) | HDAC1PARP1MAPK8GPR119JAK2 | |
| SCHEMBL11963423 | 0.85 | MAPK8 (0.40) | HDAC1PARP1MAPK8GPR119JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489663-A1 | Compounds as syk kinase inhibitors | Almirall, S.A. (ES) | 2012-08-22 | — | — | EP | disclosed |