Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.43 |
| ▸ | BRAF | P15056 | 4/20 | 0.43 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1140276 | 0.91 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2STAT3DDR2 | |
| SCHEMBL12323429 | 0.88 | ABL1 (0.47) | DDR2RAF1ABL1KCNQ3KCNQ2 | |
| SCHEMBL13237138 | 0.84 | EPHX2 (0.46) | MAPTKDM4ESMN1; SMN2ABL1KCNQ3 | |
| SCHEMBL12323403 | 0.84 | ABL1 (0.49) | DDR2RAF1ABL1EGFRKCNQ3 | |
| SCHEMBL12322745 | 0.83 | KCNQ3 (0.48) | MAPTKDM4EDDR2RAF1ABL1 | |
| SCHEMBL12324290 | 0.82 | TRPV1 (0.48) | DDR2RAF1ABL1KCNQ3KCNQ2 | |
| SCHEMBL1140304 | 0.81 | SMN1; SMN2 (0.64) | MAPTKDM4ESMN1; SMN2STAT3BRAF | |
| SCHEMBL16986700 | 0.81 | CETP (0.43) | MAPTKDM4ESMN1; SMN2TRPV1 | |
| SCHEMBL12323483 | 0.80 | LCK (0.49) | DDR2RAF1ABL1EGFRKCNQ3 | |
| SCHEMBL2427013 | 0.80 | PPARG (0.44) | MAPTKDM4ESMN1; SMN2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120196849-A1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196849-A1 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS | GLI1, SHH, SMO | MAPT 4520/4885KDM4E 1129/4885SMN1; SMN2 3605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.