Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | BCR | P11274 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | STK25 | O00506 | 1/20 | 0.36 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11964252 | 0.88 | AURKA (0.61) | AURKANTRK1AURKBRIPK1FLT3 | |
| SCHEMBL11964856 | 0.86 | AURKB (0.70) | AURKANTRK1AURKBRIPK1IGF1R | |
| SCHEMBL11964247 | 0.86 | KMT2A (0.47) | AURKAAURKBIGF1RMETAP1FLT3 | |
| SCHEMBL11964267 | 0.85 | AURKA (0.56) | AURKANTRK1AURKBRIPK1FLT3 | |
| SCHEMBL11964537 | 0.84 | AURKA (0.55) | AURKANTRK1AURKBRIPK1FLT3 | |
| SCHEMBL11964266 | 0.84 | AURKA (0.55) | AURKANTRK1AURKBRIPK1FLT3 | |
| SCHEMBL11964165 | 0.84 | FLT3 (0.56) | AURKANTRK1AURKBRIPK1FLT3 | |
| SCHEMBL11964535 | 0.84 | AURKA (0.61) | AURKANTRK1AURKBRIPK1FLT3 | |
| SCHEMBL11952787 | 0.83 | AURKA (0.50) | AURKANTRK1AURKBRIPK1IGF1R | |
| SCHEMBL11964178 | 0.83 | AURKA (0.56) | AURKANTRK1AURKBRIPK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9078902-B2 | Triazine derivatives and their therapeutical applications | NANTBIOSCIENCE, INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-20120196860-A1 | Triazine derivatives and their therapeutical applications | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196860-A1 | Triazine derivatives and their therapeutical applications | MAP3K2, MAP3K5, MAP4K2 | AURKA 877/4885NTRK1 994/4885AURKB 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.