Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.49 |
| ▸ | CETP | P11597 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | GMNN | O75496 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CXCR5 | P32302 | 2/20 | 0.49 |
| ▸ | CCR6 | P51684 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | UBE2N | P61088 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16273932 | 0.85 | SPHK2 (0.67) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL15746569 | 0.85 | SPHK2 (0.67) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL16085653 | 0.85 | SPHK2 (0.67) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL12857079 | 0.85 | SPHK2 (0.67) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL19135705 | 0.85 | SPHK2 (0.67) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL16218959 | 0.81 | SPHK2 (0.56) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL12838333 | 0.80 | SPHK2 (0.70) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL17715423 | 0.75 | SPHK2 (0.50) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL15160889 | 0.72 | SPHK2 (0.35) | SPHK2SPHK1CETPMAPTMEN1 | |
| SCHEMBL12570674 | 0.71 | SPHK2 (0.36) | SPHK2SPHK1CETPMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120195901-A1 | Compositions and Methods for Binding Lysophosphatidic Acid | LPATH, INC. | 2012-08-02 | — | — | US | disclosed |
| US-20110076267-A1 | HUMANIZED ANTIBODY COMPOSITIONS AND METHODS FOR BINDING LYSOPHOSPHATIDIC ACID | APOLLO ENDOSURGERY, INC. | 2011-03-31 | — | — | US | disclosed |
| US-20100034814-A1 | COMPOSITIONS AND METHODS FOR BINDING LYSOPHOSPHATIDIC ACID | APOLLO ENDOSURGERY, INC. | 2010-02-11 | — | — | US | disclosed |
| US-20090136483-A1 | Compositions and Methods for Binding Lysophosphatidic Acid | INNOVATUS LIFE SCIENCES LENDING FUND I, LP | 2009-05-28 | — | — | US | disclosed |
| US-20080145360-A1 | Lysolipid specific immunoglobulin for use in diagnosis, prevention and treatment of blood and cell proliferative disorders | INNOVATUS LIFE SCIENCES LENDING FUND I, LP | 2008-06-19 | — | — | US | disclosed |
| US-20080138334-A1 | Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same | SABBADINI ROGER A | 2008-06-12 | — | — | US | disclosed |
| US-20080090303-A1 | Methods and Reagents for Detecting Bioactive Lipids | APOLLO ENDOSURGERY, INC. | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100034814-A1 | COMPOSITIONS AND METHODS FOR BINDING LYSOPHOSPHATIDIC ACID | LPAR2, LPAR3, LPAR5 | SPHK2 150/4885SPHK1 237/4885CETP 220/4885 |
| US-20080145360-A1 | Lysolipid specific immunoglobulin for use in diagnosis, prevention and treatment of blood and cell proliferative disorders | CD47, SGMS1, ALG1 | SPHK2 29/4885SPHK1 21/4885CETP 60/4885 |
| US-20120195901-A1 | Compositions and Methods for Binding Lysophosphatidic Acid | LPAR2, LPAR5, LPAR1 | SPHK2 86/4885SPHK1 128/4885CETP 123/4885 |
| US-20110076267-A1 | HUMANIZED ANTIBODY COMPOSITIONS AND METHODS FOR BINDING LYSOPHOSPHATIDIC ACID | LPAR5, LPAR2, LPAR6 | SPHK2 112/4885SPHK1 160/4885CETP 144/4885 |
| US-20090136483-A1 | Compositions and Methods for Binding Lysophosphatidic Acid | LPAR2, LPAR5, LPAR1 | SPHK2 86/4885SPHK1 128/4885CETP 123/4885 |
| US-20080138334-A1 | Immune-Derived Moieties Reactive Against Bioactive Lipids, and Methods of Making and Using Same | CD47, ALG1, SGMS1 | SPHK2 32/4885SPHK1 23/4885CETP 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.