Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.34 |
| ▸ | CDK9 | P50750 | 5/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3000429 | 1.00 | IGF1R (0.41) | IGF1RSYKBTKCCNT1CDK9 | |
| SCHEMBL11967763 | 0.94 | IGF1R (0.41) | IGF1RSYKBTKCCNE1CDK2 | |
| SCHEMBL11967781 | 0.94 | IGF1R (0.41) | IGF1RSYKCCNE1CDK2GSK3B | |
| SCHEMBL3008647 | 0.94 | IGF1R (0.41) | IGF1RSYKCCNE1CDK2GSK3B | |
| SCHEMBL11967764 | 0.94 | IGF1R (0.41) | IGF1RSYKBTKCCNE1CDK2 | |
| SCHEMBL13207731 | 0.94 | IGF1R (0.41) | IGF1RSYKBTKCCNE1CDK2 | |
| SCHEMBL13207732 | 0.91 | IGF1R (0.40) | IGF1RSYKBTKCCNE1CDK2 | |
| SCHEMBL11967762 | 0.90 | IGF1R (0.41) | IGF1RSYK | |
| SCHEMBL11967765 | 0.90 | IGF1R (0.41) | IGF1RSYK | |
| SCHEMBL3010086 | 0.88 | IGF1R (0.41) | IGF1RCCNE1CDK2GSK3BCCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415340-B2 | Triazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-09 | — | — | US | disclosed |
| EP-2175933-B1 | TRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-08-22 | — | — | EP | disclosed |