Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | CDK4 | P11802 | 14/20 | 0.59 |
| ▸ | CCND1 | P24385 | 12/20 | 0.59 |
| ▸ | CCND2 | P30279 | 12/20 | 0.59 |
| ▸ | CCND3 | P30281 | 12/20 | 0.59 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.59 |
| ▸ | MARK3 | P27448 | 1/20 | 0.59 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.59 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.59 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.59 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11977091 | 0.90 | CDK4 (0.58) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL7714624 | 0.89 | CDK4 (0.70) | CSF1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL11977083 | 0.88 | CDK4 (0.69) | CSF1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL7708879 | 0.88 | CSF1R (0.71) | CSF1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL11977115 | 0.87 | CDK4 (0.70) | CSF1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL7710732 | 0.86 | CDK4 (0.74) | CSF1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL7713061 | 0.86 | CDK4 (0.71) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL7706862 | 0.85 | CDK4 (0.73) | CSF1RCDK4CCND1CCND2CCND3 | |
| SCHEMBL7710738 | 0.85 | CDK4 (0.70) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL7712735 | 0.84 | WEE1 (0.66) | CSF1RCDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324225-B2 | Pyrrolopyrimidine compounds and their uses | NOVARTIS AG (CH) | 2012-12-04 | — | — | US | disclosed |
| US-20120207763-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | ASTEX THERAPEUTICS LIMITED (GB) | 2012-08-16 | — | — | US | disclosed |
| US-20120207763-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | ASTEX THERAPEUTICS LIMITED (GB) | 2012-08-16 | — | — | US | disclosed |
| US-20090318441-A1 | Pyrrolopyrimidine Compounds and Their Uses | ASTEX THERAPEUTICS LTD. | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318441-A1 | Pyrrolopyrimidine Compounds and Their Uses | PRKDC, TK2, PNKP | CSF1R 4378/4885CDK4 4/4885CCND1 615/4885 |
| US-20120207763-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | PRKDC, TK2, PNKP | CSF1R 4378/4885CDK4 4/4885CCND1 615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.