Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17758245 | 0.77 | KCNN4 (0.52) | KCNN4MAPK1CES1TSHRALDH1A1 | |
| SCHEMBL28370279 | 0.76 | KDM4E (0.44) | KCNN4MAPK1CES1KDM4EGAA | |
| SCHEMBL28465259 | 0.75 | KDM4E (0.42) | KCNN4MAPK1CES1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL9243390 | 0.74 | GAA (0.41) | MAPTTSHRALDH1A1TDP1ALOX12 | |
| SCHEMBL6287224 | 0.71 | KCNN4 (0.47) | KCNN4MAPTCES1TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL27718739 | 0.71 | KCNN4 (0.55) | KCNN4MAPK1CES1ALDH1A1ALOX15 | |
| SCHEMBL29138685 | 0.71 | KCNN4 (0.52) | KCNN4MAPTCES1TSHRALDH1A1 | |
| SCHEMBL3225192 | 0.70 | TSHR (0.48) | KCNN4MAPTMAPK1TSHRALDH1A1 | |
| SCHEMBL450601 | 0.70 | MAPKAPK2 (0.46) | KCNN4MAPK1TSHRALDH1A1ALOX15 | |
| SCHEMBL11328818 | 0.69 | KCNN4 (0.44) | KCNN4MAPK1CES1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627638-A1 | 1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS. | Immunahr AB (SE) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012050500-A1 | 1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS. | PETTERSSON LARS (SE) | 2012-04-19 | — | — | WO | disclosed |