Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 4/20 | 0.48 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 2/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736212 | 0.93 | ATM (0.53) | ATMAPPCTSSCTSKCTSL | |
| SCHEMBL20470382 | 0.89 | ATM (0.56) | ATMAPPCTSSCTSKCTSL | |
| SCHEMBL15159951 | 0.85 | ATM (0.73) | ATMAPPCTSSCTSKCTSL | |
| SCHEMBL27459831 | 0.81 | BACE1 (0.48) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL4973190 | 0.81 | BACE1 (0.48) | ATMCTSSCTSKCTSLCTSB | |
| SCHEMBL15424011 | 0.79 | ATM (0.65) | ATMAPPCTSSCTSKCTSL | |
| SCHEMBL2736210 | 0.79 | ATM (0.65) | ATMAPPCTSSCTSKCTSL | |
| SCHEMBL13999332 | 0.79 | ATM (0.68) | ATMAPPCTSSCTSKCTSL | |
| SCHEMBL1845669 | 0.79 | ATM (0.68) | ATMAPPCTSSCTSKCTSL | |
| SCHEMBL4901020 | 0.79 | ATM (0.68) | ATMAPPCTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2487165-A1 | Modulators of pharmacokinetic properties of therapeutics | GILEAD SCIENCES, INC. (US) | 2012-08-15 | — | — | EP | disclosed |