SCHEMBL11987007

SCHEMBL11987007

CCc1cccc(CC)c1N(c1cccc(-n2ccc(C)n2)n1)c1cccc(-n2ccc(C(F)(F)F)n2)n1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.46
NPC1 O15118 3/20 0.46
RAB9A P51151 2/20 0.46
ATM Q13315 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
PRMT6 Q96LA8 1/20 0.35
IDH1 O75874 1/20 0.34
IDH2 P48735 1/20 0.34
PDE10A Q9Y233 1/20 0.34
MPO P05164 1/20 0.30
DRD2 P14416 1/20 0.30
DRD3 P35462 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11987622 0.94 IDH1 (0.37) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL11987008 0.85 MAPT (0.48) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL11987002 0.83 NPC1 (0.46) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL11987623 0.77 MAPT (0.36) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL11987648 0.77 IDH1 (0.37) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL11987006 0.74 MAPT (0.58) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL11987645 0.67 NPC1 (0.45) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL197523 0.67 MAPT (1.00) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL26061296 0.67 MAPT (0.71) MAPTNPC1RAB9AATMSMN1; SMN2
SCHEMBL14198213 0.66 NPC1 (0.40) MAPTNPC1RAB9AATMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120309970-A1 PLATINUM COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE UDC IRELAND LTD. (IE) 2012-12-06 US disclosed
US-8247091-B2 Platinum complex compound and organic electroluminescent device FUJIFILM CORPORATION (JP) 2012-08-21 US disclosed
US-20110234090-A1 PLATINUM COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE FUJIFILM CORPORATION (JP) 2011-09-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120309970-A1 PLATINUM COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE L1CAM, LIG1, ZC3HAV1L MAPT 1900/4885NPC1 3900/4885RAB9A 1622/4885
US-20110234090-A1 PLATINUM COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE L1CAM, LIG1, ZC3HAV1L MAPT 1900/4885NPC1 3900/4885RAB9A 1622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.