Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046678 | 0.81 | PDE10A (0.45) | PDE10APDE7APDE3A | |
| SCHEMBL12046680 | 0.77 | CCNA2 (0.45) | PDE10A | |
| SCHEMBL12046632 | 0.76 | PDE7A (0.43) | PDE10APDE7APDE3A | |
| SCHEMBL12046682 | 0.73 | CCNA2 (0.49) | — | |
| SCHEMBL12046636 | 0.72 | CCNA2 (0.40) | PDE10APDE7A | |
| SCHEMBL30759617 | 0.71 | CCNA2 (0.43) | PDE10A | |
| SCHEMBL27122717 | 0.71 | CCNA2 (0.43) | PDE10A | |
| SCHEMBL1160202 | 0.71 | UGCG (0.40) | PDE10APDE7APDE3A | |
| SCHEMBL27119215 | 0.70 | PDE7A (0.38) | PDE10APDE7APDE3A | |
| SCHEMBL22626454 | 0.70 | PDE7A (0.37) | PDE10APDE7APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459551-B1 | DIHYDROBENZOINDAZOLES | MERCK SHARP & DOHME (NL) | 2014-07-02 | — | — | EP | disclosed |
| EP-2459551-A1 | DIHYDROBENZOINDAZOLES | MSD Oss B.V. (NL) | 2012-06-06 | — | — | EP | disclosed |
| US-8071589-B2 | Dihydrobenzoindazoles | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| US-20110028451-A1 | Dihydrobenzoindazoles | N.V. ORGANON (NL) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028451-A1 | Dihydrobenzoindazoles | DHODH, BRDT, HSD17B11 | PDE10A 2445/4885PDE7A 2158/4885PDE3A 931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.